According to a Toronto Paramedics spokesperson, emergency services were called to Spadina Avenue and Nassau Street around 3:15 a.m. Sunday.
The spokesperson said one person was pronounced dead on the scene.
Paramedics transported two men to a local trauma centre. One male was in life-threatening condition and the other was in serious condition.
The male in life-threatening condition later died from his injuries, Toronto Homicide Det. Sgt. Mike Carbone told media later Sunday morning.
A fourth person left the scene and went to a hospital by taxi, but the exact nature of their injuries is unknown.
One other person was also taken to hospital, although it’s unclear how they got there.
As of Sunday morning, Toronto police haven’t released any suspect information.
Police have closed Spadina Avenue between College Street and Dundas Street West while officers investigate.
Anyone with information is being asked to call 14 Division at 416-808-1400.